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为评价交感传出纤维对颈动脉体多巴胺(DA)代谢的影响,切除一侧颈上神经节后,将鼠置于慢性低氧环境(10％o2+90％N_2)1或3周。结果发现,颈动脉体完整组中,慢性低氧使DA含量增加、转换加快。切除颈上神经节只能减弱却不能消除低氧时的多巴胺能反应。为确证交感节前还是节后纤维参与DA代谢的控制,在横断一侧节前颈交感干或用胍乙啶选择性地损毁节后纤维并置鼠于同样低氧环境后发现:节前颈交感干横断减弱了低氧时的多巴胺能反应,施用胍乙啶对此并无影响。本文认为,慢性低氧期间,交感传出纤维可能激活球状细胞内DA的合成与释放,而与DA代谢调制有关的交感传出纤维可能是节前纤维。
To assess the effect of sympathetic afferent fibers on carotid body dopamine (DA) metabolism, the rats were placed in chronic hypoxia (10% o2 + 90% N2) for 1 or 3 weeks after excision of the superior cervical ganglion. The results showed that, in the complete carotid body group, chronic hypoxia increased DA content, the conversion speed up. Excision of the superior cervical ganglion can only attenuate but does not eliminate the dopaminergic response to hypoxia. In order to confirm the sympathetic preganglionic or postganglionic fibers involved in the control of DA metabolism in the transverse section of the anterior cervical sympathectomized or guanidine ethyl selective destruction of postganglionic fibers and set the mouse in the same hypoxia environment found: Sympathetic transection weakens the dopaminergic response to hypoxia and does not affect guanidine use. This paper suggests that during chronic hypoxia, sympathetic fibers may activate the synthesis and release of DA in globular cells, whereas sympathetic fibers associated with DA metabolism may be preganglionic fibers.