【摘 要】
：
目的:观察洛伐他汀联合GP方案(吉西他滨(Gemcitabine)+顺铂(Cis-platin))治疗中晚期非小细胞肺癌的临床疗效、不良反应等,并探讨其可能的机制.方法:将103例中晚期非小细胞肺
【机 构】
：
湖南省益阳市第一中医院,413000
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目的:观察洛伐他汀联合GP方案(吉西他滨(Gemcitabine)+顺铂(Cis-platin))治疗中晚期非小细胞肺癌的临床疗效、不良反应等,并探讨其可能的机制.方法:将103例中晚期非小细胞肺癌患者随机分为两组,治疗组(53例)采用洛伐他汀加GP方案治疗,对照组(50例)采用单纯GP方案化疗.结果:治疗组和对照组的有效率(CR+PR)分别为49.1%和32.0%(P>0.05),临床获益率(CR+PR+SD)分别为83.0%和64.0%(P<0.05).治疗组生存质量高于对照组(P<0.05);对照组白细胞减少、血红蛋白下降和恶心、呕吐等病例数多于治疗组(P<0.05).治疗组在治疗后血清脂蛋白(a)和乳腺癌耐药蛋白降低(P<0.01).结论:洛伐他汀与化疗同时应用治疗非小细胞肺癌,能减轻化疗的某些不良反应,提高临床获益率,改善患者生存质量.其可能的机制与降低血清脂蛋白(a)和乳腺癌耐药蛋白有关.
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