[背景]丙烯酰胺是一种常见的膳食暴露物,它可以穿过人的胎盘。丙烯酰胺已被列为可能的人类致癌物,在啮齿类动物中人们观察到丙烯酰胺的发育毒性。[目的]在前瞻性欧洲母子研究中,探讨产前暴露于丙烯酰胺与分娩结果之间的关联。[方法]2006—2010年间,测定在丹麦、英国、希腊、挪威和西班牙招募的1101名单胎怀孕妇女的脐带血中,血红蛋白(Hb)丙烯酰胺加合物及其代谢产物环氧丙酰胺(反映在怀孕的最后几个月中的累积暴露)的含量。通过食物频率问卷评估孕妇的饮食。[结果]丙烯酰胺和环氧丙酰胺血红蛋白加合物与出生体重及头围减少相关联,具有统计学显著性。校正胎龄和国家后,在最高与最低四分位数的丙烯酰胺血红蛋白加合物水平的婴儿出生体重的估算差异为-132g(95%CI:-207~-56);相应的头围差异为-0.33cm(95%CI:-0.61~-0.06)。这些结果类似于非吸烟者的婴儿,并且在不同国家是一致的,校正与低出生体重相关因素后,差异仍然存在。孕妇食用富含丙烯酰胺的食物,如炸土豆,与脐带血丙烯酰胺加合物水平升高及低出生体重相关。[结论]膳食丙烯酰胺暴露与出生体重降低和头围减少相关。在怀孕期间食用特定的食物与较高的子宫内丙烯酰胺暴露相关。如果得到证实,这些研究结果提示怀孕妇女应减少摄取含丙烯酰胺的食物。 [Background] Acrylamide is a common dietary exposure that penetrates the human placenta. Acrylamide has been listed as a possible human carcinogen, and developmental toxicity of acrylamide has been observed in rodents. [Objective] To investigate the relationship between prenatal exposure to acrylamide and delivery outcomes in a prospective European mother-child study. [Method] From 2006 to 2010, hemoglobin (Hb) acrylamide adduct and its metabolite glycoproteinamide were measured in cord blood of 1,101 singleton pregnant women recruited in Denmark, the United Kingdom, Greece, Norway and Spain Cumulative exposure in the last months of pregnancy). Food frequency questionnaire to assess the diet of pregnant women. [Result] The correlation between acrylamide and epoxypropylamide hemoglobin adduct was associated with birth weight and head circumference reduction, with statistical significance. The estimated difference in birth weight at the highest and lowest quartiles of acrylamide hemoglobin adduct levels after correction for gestational age and country was -132 g (95% CI: -207 to -56); the corresponding head circumference difference -0.33 cm (95% CI: -0.61 -0.06). These results are similar to those of non-smokers and are consistent in different countries, with differences still remaining after correlating factors associated with low birth weight. Pregnant women consume foods rich in acrylamide, such as fried potatoes, associated with elevated umbilical cord blood acrylamide adduct levels and low birth weight. [Conclusion] Dietary acrylamide exposure is related to the reduction of birth weight and head circumference. Eating certain foods during pregnancy is associated with higher intrauterine acrylamide exposure. If confirmed, these findings suggest that pregnant women should reduce their intake of food containing acrylamide.