论文部分内容阅读
第三代头孢菌素的药动学参数很不相同,因而每种制剂均需选择各自的剂量和用法;虽然它们的抗菌谱适用于需氧G~-菌感染,但抗菌后效应有限;不同疾病时蛋白结合率不同,作用部位的药浓度与血浓度也常不一致,这些在选择剂量时都需考虑。肾功能降低影响大多数第三代头孢菌素的清除,肝病一般不需调整剂量,小儿和老年病人应根据其药动学资料调整剂量。
Third-generation cephalosporins pharmacokinetic parameters are very different, so each preparation need to choose their own dosage and usage; although their antibacterial spectrum for aerobic G ~ - bacteria infection, but antibacterial effect is limited; different Disease protein binding rate is different, the role of the site of the drug concentration and blood concentration are often inconsistent, these should be considered in the choice of dose. Decreased renal function affect the majority of third-generation cephalosporin removal, liver disease generally do not need to adjust the dose, pediatric and elderly patients should be based on their pharmacokinetic data to adjust the dose.