In this paper, a new numerical simulation approach is proposed for the study of open-loop frequency response of a chaotic masking system. Using Chua’s circuit and the Lorenz system as illustrative examples, we have shown that one can employ chaos synchronization to separate the feedback network from a chaotic masking system, and then use numerical simulation to obtain the open-loop synchronization response, the phase response, and the amplitude response of a chaotic masking system. Based on the analysis of the frequency response, we have also proved that changing the amplitude of the exciting (input) signal within normal working domain does not influence the frequency response of the chaotic masking system. The new numerical simulation method developed in this paper can be extended to consider the open-loop frequency response of other systems described by differential or difference equations.