Chemometric identification of canonical metabolites linking critical process parameters to monoclona

来源 :中国化学工程学报:英文版 | 被引量 : 0次 | 上传用户：lk_wuyong

【摘要】

：

A deeper understanding of the biological events occurring when bioprocess parameters changed will be of great value in improving the monoclonal antibodies (mAbs

【作者】

：

Lijuan Shen Xu Yan Lei Nie Wen

【机构】

：

PharmaceuticalInformaticsInstitute,ZhejiangHisunPharmaceuticalCo.

【出处】

：

中国化学工程学报:英文版

【发表日期】

：

2019年5期

【关键词】

：

CANONICAL METABOLITES CHEMOMETRICS Critical process PARAMETERS Metabolomics Prot

【基金项目】

：

the Science and Technology Development Program of Zhejiang Province (2017C03003).

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A deeper understanding of the biological events occurring when bioprocess parameters changed will be of great value in improving the monoclonal antibodies (mAbs) production. Design of experiment (DoE) was applied to investigate the effect of process param

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