Early massively-parallel sequencing studies have revealed the mutational landscape of protein-coding genes in prostate cancer.However,most of these studies have not explored the extensive influence of genomic rearrangement in prostate cancer.In a recent Cell article,Baca and colleagues used whole-genome sequencing to tackle this issue,comprehensively surveying the abundance of genomic rearrangements present in a large cohort of 57 prostate cancers.They characterized a wide-spread phenomenon termed ‘chromoplexy\',which may drive cancer evolution through the phenomena of punctuated equilibrium by concurrently dysregulating numerous cancer genes across multiple chromosomes.