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目的探讨对梅毒血清固定患者白细胞介素(IL)水平检测的临床意义。方法选择2009年1月—2013年1月深圳市第七人民医院收治的35例梅毒血清固定患者为观察组、40例治疗后快速血浆反应素试验(RPR)转阴的患者为对照1组,另选择40名健康体检者作为对照2组,对各组进行血清IL-2、IL-12、IL-4、IL-10水平检测及自然杀伤(NK)细胞水平测定。结果观察组血清IL-2、IL-12水平低于两个对照组(P=0.000),血清IL-4、IL-10水平高于两个对照组(P=0.000~0.040),对照1组血清IL-4、IL-10水平高于对照2组(P=0.043、0.031),对照2组NK细胞所占百分率高于观察组(P=0.000),差异均有统计学意义。结论梅毒血清固定患者存在细胞免疫功能抑制,可能是血清固定形成的原因之一。
Objective To investigate the clinical significance of detection of interleukin (IL) in syphilis serum. Methods Thirty-five patients with syphilis were enrolled in the Seventh People’s Hospital of Shenzhen City from January 2009 to January 2013. The patients in the 40 patients who underwent RPR were negative in the control group 1, Forty healthy control subjects were selected as control group. Serum levels of IL-2, IL-12, IL-4 and IL-10 were measured and NK cell levels were measured in each group. Results The serum levels of IL-2 and IL-12 in the observation group were lower than those in the two control groups (P = 0.000). The levels of serum IL-4 and IL-10 in the observation group were higher than those in the two control groups (P = 0.000-0.40) The levels of IL-4 and IL-10 in serum were higher than those in control group 2 (P = 0.043,0.031). The percentage of NK cells in control 2 group was higher than that in observation group (P = 0.000). The differences were statistically significant. Conclusion Syphilis serum in patients with suppressed cellular immune function may be one of the reasons for the formation of serum fixation.