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目的制备凡胶软膏,并考察其体外释放度。方法以无水葡萄糖为对照品,以白及多糖为指标,0.9%氯化钠溶液为释放介质,0.2%蒽酮-硫酸试液为染色剂,采用透析袋法研究凡胶软膏的体外释药特性。结果 4 h内白及多糖累积释放度为61.8%,为速释期;4 h以后药物的释放度为38.2%,为缓释期,48 h内累积释放度为97.8%。结论凡胶软膏具有缓释性,每12 h使用一次可保持疗效。该方法考察凡胶软膏的体外释放度,操作便利,方法稳定,结果可靠。
Objective To prepare all ointment and investigate its in vitro release. Methods Using anhydrous glucose as reference substance, white and polysaccharide as index, 0.9% sodium chloride solution as the release medium, 0.2% anthrone-sulfuric acid test solution as stain, dialysis bag method was used to study the in vitro drug release characteristic. Results The cumulative release of white and polysaccharides was 61.8% within 4 h. The release rate was 38.2% after 4 h. The release rate was 97.8% within 48 h. Conclusion All ointment with sustained release, once every 12 h to maintain efficacy. The method examines the in vitro release of alloil ointment, convenient operation, the method is stable and the result is reliable.