多发性骨髓瘤多发生于40岁以上成人,由于医疗条件的改善、预期寿命的延长,本病患者时有所见。氮质血症、高尿酸血症、高钙血症是本病常见的并发症,当发生这些并发症而不予合理的处理,常可危及生命。在这种情况下,如不适当改善肾功,而给予常规烷化剂治疗,常常事与愿违,弊多利少。本文报道的2例,就是值得吸取的经验教训。 Multiple myeloma and more occurred in adults over the age of 40, due to the improvement of medical conditions, the life expectancy of the extension, the patients have seen. Azotemia, hyperuricemia, hypercalcemia is a common complication of the disease, when these complications occur without reasonable treatment, often life-threatening. In this case, if improper improvement of renal function, and given conventional alkylating agent treatment, often contrary to expectations, more harm than good. Two cases reported in this article is worth learning from.