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目的探讨paxillin、vinculin在胃癌及癌前病变中的表达及对胃癌预后的影响。方法应用免疫组化SP法检测20例正常胃黏膜、20例胃黏膜慢性炎、10例萎缩性胃炎、12例胃黏膜上皮内肿瘤和50例胃腺癌中的paxillin、vinculin表达。结果paxillin、vinculin两种细胞骨架蛋白在正常胃黏膜高表达,随着病变加重而表达减弱。在胃癌中的表达显著低于癌前病变(P<0.05),且与胃腺癌的浸润深度、淋巴结转移、TNM分期及生存期等生物学行为相关。结论paxillin、vinculin两种细胞骨架蛋白在胃黏膜癌变过程中起作用,两种蛋白的失表达对胃癌的预后有重要的临床意义。
Objective To investigate the expression of paxillin and vinculin in gastric cancer and precancerous lesions and the prognosis of gastric cancer. Methods The expressions of paxillin and vinculin in 20 normal gastric mucosa, 20 chronic gastric mucosa, 10 atrophic gastritis, 12 gastric intraepithelial neoplasia and 50 gastric adenocarcinoma were detected by immunohistochemical SP method. Results Both paxillin and vinculin cytoskeleton proteins were highly expressed in normal gastric mucosa and weakened with the increase of lesions. It was significantly lower in gastric cancer than in precancerous lesions (P <0.05), and was related to the biological behavior of gastric adenocarcinoma such as the depth of invasion, lymph node metastasis, TNM stage and survival time. Conclusion Both paxillin and vinculin cytoskeletal proteins play roles in the carcinogenesis of gastric mucosa. The loss of expression of these two proteins has important clinical significance for the prognosis of gastric cancer.