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探讨小儿急性肾炎对循环内皮细胞与一氧化氮的改变。方法随机选择急性肾炎组20例，健康儿童40例为对照组。住院翌日晨采静脉血3ml、1ml于肝素抗凝管中待测NO水平，2ml由3．8％枸橼酸钠抗凝，测定CEC用。并对测定结果进行统计学分析。结果对照组循环内皮细胞（CEC）为20．5±7．6n／0．9μl，肾炎极期为47．8±31.7n／0．9μl，肾炎恢复期27．7±9．9n/0．9μl。与正常对照组比较，小儿肾炎极期明显高于对照组和恢复期（P＜0．01）。一氧化氮（NO）仅测10例，正常组19．19±9．9μmol／L，肾炎组24．42±10．32μmol／L，两组对比，有增加趋势。结论小儿急性肾炎时CEC明显高于正常对照组，同时高于恢复期，结果表明循环内皮细胞在小儿急性肾炎的发生发展中起着重要的作用，因此动态观察CEC可作为判断肾炎恢复的标准之一。急性肾炎患儿NO水平与CEC是正相关，提示NO参与了小儿急性肾炎的致病过程。
To investigate the changes of circulating endothelial cells and nitric oxide in pediatric acute nephritis. Methods 20 cases of acute nephritis group and 40 healthy children were randomly selected as the control group. In the morning of the hospital the following morning, blood samples were collected in 3 ml of venous blood, 1 ml of NO level to be tested in the heparin anticoagulant tube, and 2 ml of anticoagulant solution of 3.8% sodium citrate to determine CEC use. The results of the statistical analysis. Results In the control group, the circulating endothelial cells (CEC) was 20.5 ± 7.6n / 0.9μl, the nephritis period was 47.8 ± 31.7n / 0.9μl, and the nephritis recovery period was 27.7 ± 9.9n / 0. 9μl. Compared with the normal control group, the nephritis period was significantly higher than the control group and convalescent (P <0.01). Nitric oxide (NO) was measured only in 10 cases, normal group 19.19 ± 9.9μmol / L, nephritis group 24.42 ± 10.32μmol / L, compared with the two groups, an increasing trend. Conclusions CEC in children with acute nephritis is significantly higher than that in normal control group and higher than recovery stage. The results show that circulating endothelial cells play an important role in the occurrence and development of children with acute nephritis. Therefore, dynamic observation of CEC can be used as a criterion to judge nephritis recovery one. Acute nephritis in children with NO levels and CEC is positively correlated, suggesting that NO involved in the pathogenesis of acute nephritis in children.