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海带粗提物是用市售海带以水冷浸、95％乙醇沉淀提出的一种白色固体物质,主要含藻朊酸。我们在普筛发现其对小白鼠急性辐射损伤具有预防作用的基础上,又以四种剂量分批作了近400只小白鼠预防试验。当照射剂量为900拉德、照射前半小时将海带粗提物水溶液以50～125mg/kg剂量腹腔注射时,可提高小白鼠活存率22.5～49.0％。其活存率随给药剂量增加而提高(每个剂量、预防组存活率与对照组相比P值均小于
The crude kelp extract was a white solid substance prepared by commercial cold-water immersion in seaweed and precipitated with 95% ethanol, mainly containing alginic acid. We discovered that on the basis of its preventive effect on acute radiation damage in mice, we conducted a preventive test of nearly 400 mice in batches with four doses. When the radiation dose was 900 rads and the kelp extract aqueous solution was injected intraperitoneally at a dose of 50-125 mg/kg half an hour before irradiation, the viability of the mice could be increased by 22.5 to 49.0%. The survival rate increased with the increase of the administration dose (the P value of each dose and prevention group was lower than that of the control group.