Neighborhood has always been of significant interest to built environment stockholders as a basic planning unit. However, any discussion in these concs, without drawing attention to sustainable microclimate approaches, would still in a mess at a time of increasing population and climate change. Emergence of the sustainable development concept at the mid-20th century and its emphasis led to increasing crucial role that the urban green infrastructure along with reflective materials can play in mitigating neighborhood microclimate’s symptoms of climate change. Considering the lack of studies for urban heat island (UHI) in hot arid regions, particularly in Egypt and the limited number of studies concing the numerical simulation of all mitigation strategies incorporated, this research studies the mitigation of UHI phenomenon in a case study in Cairo in present and future (2020, 2050 and 2080) through applying the criteria of tree lines, green roofs, high albedo pavements and shading structures within the neighborhood sustainability assessment tool (Leadership in Energy and Environmental Design for Neighborhood; LEED-ND). The microclimatic numerical CFD simulations of ENVI-met 4.0 was used following the measurement of LAI and Albedo of selected Egyptian trees to assess UHI through air and radiant temperature differences before and after applying mitigation strategies. Results demonstrate a considerable ability to acclimatize the microclimate in terms of better conditions in present and future.