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目的:考察头孢硫脒在25℃和37℃下与腹膜透析液配伍的稳定性。方法:将头孢硫脒加入腹膜透析液中,混合均匀后,在25℃和37℃下于0,1,2,4,6,8 h时采用一阶导数分光光度法,测定头孢硫脒的含量,同时记录外观变化及pH值。结果:0-8 h内混合液外观基本无变化,37℃时pH值略有下降,头孢硫脒的含量没有明显变化。结论:在上述条件下,头孢硫脒在腹膜透析液中,含量基本稳定。
Objective: To investigate the stability of cefathiamidine compatibility with peritoneal dialysis solution at 25 ℃ and 37 ℃. Methods: Cefathiamidine was added into the peritoneal dialysis solution and mixed well. The first derivative spectrophotometry was used at 0, 1, 2, 4, 6 and 8 h at 25 ℃ and 37 ℃ to determine the concentration of cefathiamidine Content, while recording changes in appearance and pH value. Results: There was no change in the appearance of the mixed solution within 0-8 h, pH value decreased slightly at 37 ℃, and the content of cefathiamidine did not change significantly. Conclusion: Under the above conditions, the content of cefathiamidine in peritoneal dialysis solution is basically stable.