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类风湿关节炎(RA)是一种常见的自身性免疫疾病,其主要病理特征为滑膜组织大量增生,从而促使炎症因子聚集以及骨侵蚀发生,在此过程中滑膜中血管翳形成扮有重要角色,其中低氧诱导因子-1α(HIF-1α)、血管内皮生长因子(VEGF)能够促使RA的血管翳生成,两者是导致RA患者关节炎症和关节破坏以及滑膜组织肿瘤样增生的主要因素。而HIF-1α能够促使RA患者炎症因子和基质金属蛋白的分泌,VEGF则能够直接促使血管翳形成,最终两者能导致病情进一步发展。HIF-1α,VEGF在RA患者滑膜中高表达,可作为今后治疗RA提供新的靶点。
Rheumatoid arthritis (RA) is a common autoimmune disease whose main pathological feature is massive proliferation of synovial tissue, which promotes the aggregation of inflammatory factors and the erosions of the bone, in the process of which the synovial pannus plays a role Important roles, including hypoxia-inducible factor-1α (HIF-1α), vascular endothelial growth factor (VEGF) can promote the angiogenesis of RA, both of which lead to RA patients with joint inflammation and joint destruction and tumor-like synovial hyperplasia major factor. HIF-1α can promote the secretion of inflammatory cytokines and matrix metalloproteinases in patients with RA. VEGF can directly promote the formation of blood vessels, and eventually both can lead to the further development of the disease. HIF-1α and VEGF are highly expressed in the synovium of patients with RA, which may provide a new target for the future treatment of RA.