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结肠粘膜在腺瘤癌变的复杂过程中,初期可能是由于氧自由基活性增高引起DNA破坏及基因突变所致。抗氧化剂能清除自由基。维生素A、维生素E和维生素C是有效的抗氧化剂,其血清浓度和结直肠癌发生的危险性成反比。本研究旨在评价口服维生素C、维生素E、和β-胡萝卜素对腺瘤性息肉病人的结肠隐窝细胞增生的作用。 病人与方法:40例经组织学检查证实有直径>
In the complex process of adenoma carcinogenesis, colon mucosa may be initially caused by DNA damage and gene mutation due to increased oxygen free radical activity. Antioxidants can scavenge free radicals. Vitamin A, vitamin E, and vitamin C are effective antioxidants and their serum concentration is inversely proportional to the risk of colorectal cancer. The aim of this study was to evaluate the effect of oral vitamin C, vitamin E, and beta-carotene on colon crypt cells in patients with adenomatous polyps. Patients and Methods: 40 cases confirmed by histological examination of diameter>