老年人可引起抗生素药动学的变化,使副作用增加。一般,严重感染的经验治疗是氨基甙类并用β内酰胺类抗生素。氨基甙类有严重副作用,特别对老年患者。氨曲南(Aztreonam)是第一个新一代单环β内酰胺类抗生素,对革兰氏阴性需氧菌极有效,但对革兰氏阳性菌或厌氧菌无效;对于那些原有肾功能损害或在脓毒病时继发肾功能衰竭的严重感染老人,可代替氨基甙类。氟氯西林(Flucloxacillin)则是一个抗青霉素酶的青霉素。 Elderly people can cause changes in antibiotic pharmacokinetics, so that side effects increased. In general, the empirical treatment of severe infections is aminoglycosides and beta-lactam antibiotics. Aminoglycosides have serious side effects, especially in the elderly. Aztreonam is the first of a new generation of monobactams that are highly effective against Gram-negative aerobes but not against Gram-positive or anaerobic bacteria. For those with previous renal function Seriously infected elderly people who compromise or secondary to renal failure at sepsis may substitute for aminoglycosides. Flucloxacillin is a penicillin-resistant penicillinase.