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目的研究胃黏膜组织中LKB1和ARID1A基因表达与胃癌发生和发展的关系。方法 32例手术切除的胃癌组织标本、10例正常胃组织及18例胃炎组织标本利用组织芯片技术,通过免疫组织化学方法 ,检测LKB1和ARID1A的阳性表达率。结果在胃癌组织中LKB1和ARID1A阳性率(15.63%、34.38%)较胃炎(66.67%、55.56%)和正常胃组织(80.00%、60.00%)明显降低(P<0.05)。胃癌伴淋巴结转移患者LKB1和ARID1A阳性率与胃癌无淋巴结转移患者比较,差异有统计学意义(P<0.05);胃癌不同浸润深度LKB1和ARID1A阳性率比较,差异有统计学意义(P<0.05);胃癌不同病理组织分型LKB1和ARID1A阳性率比较,差异无统计学意义(P>0.05)。结论 LKB1和ARID1A在胃癌组织中的表达缺失,与胃癌转移和浸润密切相关,且在胃癌发生发展的不同环节可能为相对独立而又相互作用的调控基因。
Objective To study the relationship between the gene expression of LKB1 and ARID1A in gastric mucosa and the occurrence and development of gastric cancer. Methods 32 cases of gastric cancer tissue specimens, 10 cases of normal gastric tissue and 18 cases of gastritis tissue samples using tissue microarray technology, by immunohistochemistry to detect LKB1 and ARID1A positive expression rate. Results The positive rate of LKB1 and ARID1A in gastric cancer tissues was significantly lower than that in gastritis (66.67%, 55.56%) and normal gastric tissues (80.00%, 60.00%) (15.63% and 34.38%, P <0.05). The positive rates of LKB1 and ARID1A in gastric cancer with lymph node metastasis were significantly different from those without lymph node metastasis in gastric cancer (P <0.05). The positive rates of LKB1 and ARID1A in gastric cancer with different depth of invasion were significantly different (P <0.05) There was no significant difference in the positive rates of LKB1 and ARID1A between different pathological types of gastric cancer (P> 0.05). Conclusions LKB1 and ARID1A are absent in gastric cancer tissues and are closely related to metastasis and infiltration of gastric cancer. They may be relative independent and interacting genes in different stages of gastric cancer.