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研究了有机磷农药净地灵对大鼠肝微粒体细胞色素Ｐ４５０、细胞色素ｂ５、苯胺羟化酶及全血胆碱酯酶活性的影响。结果表明：以净地灵１ｍｇ／ｋｇ灌胃，每天１次，连续１周后，对大鼠肝微粒体细胞色素Ｐ４５０有明显抑制作用，对细胞色素ｂ５和苯胺羟化酶无显著影响。大鼠按净地灵１ｍｇ／ｋｇ经口１次授药后，对全血胆碱酯酶活性影响的时相效应表明，其最大抑制作用是在授药后２ｈ，授药后２４ｈ胆碱酯酶活性基本恢复至正常水平。根据在亚慢性实验中期（４５ｄ）和结束时（９０ｄ）分别测定各组动物全血胆碱酯酶活性的结果，表明该农药对大鼠的最大无作用剂量为０．０５ｍｇ／ｋｇ。
The effect of organophosphate pesticide net root on the activities of cytochrome P450, cytochrome b5, aniline hydroxylase and whole blood cholinesterase in rat liver microsomes was studied. The results showed that: 1mg / kg of gatifloxacin, 1 times a day for 1 week after the rat liver microsomal cytochrome P450 significant inhibition of cytochrome b5 and aniline hydroxylase no significant effect. After the rats were treated with 1mg / kg of SGP, the time-phase effect on the activity of cholinesterase in whole blood showed that the maximal inhibitory effect was that after 2h, Enzyme activity returned to normal levels. According to the result of measuring the whole blood cholinesterase activity in the middle of the subchronic experiment (45d) and the end (90d), the maximum non-action dose of the pesticide to the rats was 0.05mg / kg.