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为研究丙戊酸钠对癫痫模型大鼠认知、行为学和脑电图的影响,本次研究选取了60只健康大鼠,随机分为3组(对照组,癫痫组,丙戊酸钠组),每组20只。癫痫组与丙戊酸钠组大鼠通过氯化锂-毛果芸香碱诱导成为癫痫大鼠。造模完成后,给予3组大鼠灌胃给药,对照组与癫痫组使用生理盐水,丙戊酸钠组使用丙戊酸钠,6小时1次,持续5 d。5 d后发现癫痫组与丙戊酸钠组大鼠认知功能显著下降,脑电图频率减慢以及波幅显著增高;与癫痫组相比,丙戊酸钠组癫痫发作次数明显减少,持续时间明显降低。这提示丙戊酸钠可改善癫痫大鼠的认知功能、行为学及脑电图异常。
In order to study the effect of sodium valproate on cognition, behavior and electroencephalography in epilepsy model rats, 60 healthy rats were randomly divided into 3 groups (control group, epilepsy group, sodium valproate Group), 20 in each group. Epilepsy group and sodium valproate group rats induced by lithium chloride - pilocarpine become epileptic rats. After the model was established, three groups of rats were given intragastric administration, the control group and the epilepsy group were given saline, the sodium valproate sodium group was used once every 6 hours for 5 days. After 5 days, the cognitive function of epilepsy group and sodium valproate group was significantly decreased, the frequency of EEG was slowed down and amplitude was significantly increased. Compared with epilepsy group, the number of epileptic seizures significantly decreased in sodium valproate group, duration Obvious reduction. This suggests that sodium valproate can improve cognitive function, behavioral and EEG abnormalities in epileptic rats.