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[目的]探讨新生儿窒息后血清S-100B蛋白含量的变化及其临床意义。[方法]采用酶联免疫吸附试验双抗体夹心法检测40例足月窒息新生儿(轻度窒息24例,重度窒息16例)出生后d1、d3的血清S-100B蛋白含量,并与20例正常足月新生儿进行对照。[结果]窒息新生儿血清S-100B蛋白水平显著高于正常对照组,窒息程度越重,血清S-100B蛋白水平越高(F=11.72,P﹤0.01)。窒息后脑损伤程度越重,d1血清S-100B蛋白水平越高(F=25.97,P﹤0.01),中、重度HIE患儿生后d3血清S-100B蛋白水平与无脑损害及轻度HIE患儿相比仍然较高(F=84.06,P﹤0.01)。[结论]新生儿窒息后血清S-100B蛋白含量的变化有助于缺氧缺血性脑损伤严重程度的判断。
[Objective] To investigate the change of serum S-100B protein level and its clinical significance after neonatal asphyxia. [Methods] Serum S-100B protein levels of 40 full-term asphyxia neonates (24 with mild asphyxia and 16 with severe asphyxia) were measured by enzyme-linked immunosorbent assay (ELISA) Normal term neonates were controlled. [Results] Serum levels of S-100B protein in neonates with asphyxia were significantly higher than those in control group. Serious asphyxia and serum S-100B protein levels were higher (F = 11.72, P <0.01). Serum levels of S-100B protein in d1 serum were higher (F = 25.97, P <0.01), and the levels of serum S-100B protein in d3 of moderate and severe HIE patients were associated with no brain damage and mild HIE Children were still higher (F = 84.06, P <0.01). [Conclusion] The change of serum S-100B protein content after neonatal asphyxia contributes to the judgment of the severity of hypoxic-ischemic brain injury.