侵袭性曲霉病(IA)发病率逐年增加,病死率居高不下。早期诊断能提高患者的生存率。但IA的早期诊断存在困难,因为特征性的临床和影像表现出现较迟,而组织活检又受到患者一般状况限制。因此,非创伤性诊断方法受到重视。半乳甘露聚糖(GM)是曲菌属的细胞壁组成成分,随着霉菌的生长被释放到外界中。由伯瑞(Bio-Rad)实验室研制的借由单克隆抗体双夹心(double-sandwich)酵素免疫分析的检测方法于2003年通过美国食品药品监督管理局的审核。该检测试剂盒具有良好的可重复 The incidence of invasive aspergillosis (IA) increased year by year, the high mortality. Early diagnosis can improve patient survival. However, the early diagnosis of IA is difficult because of the late appearance of characteristic clinical and imaging findings, which in turn is limited by the general condition of the patient. Therefore, non-invasive diagnostic methods have been taken seriously. Galactomannan (GM), the cell wall component of Aspergillus, is released to the environment as the mold grows. The assay, developed by Bio-Rad Laboratories’ monoclonal antibody double-sandwich enzyme immunoassay, was approved by the U.S. Food and Drug Administration in 2003. The test kit is well repeatable