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一、下丘脑内分泌概况:1955年Saffsan等首次报告促肾上腺皮质激素释放因子(CRF),1969年Guillemin等人工合成促甲状腺素释放激素(TRH),并于1971年确定促性腺激素释放激素(GnRH)结构。以后,应用凝胶滤过,层析技术分离提纯并鉴定的下丘脑激素,不下十种,每种垂体前叶激素至少有一种释放因子或促进和抑制两种因子。下丘脑是内分泌、行为和植物性神经的整合中枢,下丘脑激素是指下丘脑产生的具有内分泌活性的神经肽,通过与垂体的密切联系调控内分泌机能,并作为神经递质,神经调制者对大脑皮层和边缘系统发挥影响作用。二、下丘脑激素的产生及分布:已知下丘脑有肽类激素合成酶和GnRH、TRH降解
First, the hypothalamus of endocrine profiles: Saffsan et al 1955 for the first time reported corticotropin releasing factor (CRF), 1969 Guillemin and other synthetic thyrotropin releasing hormone (TRH), and in 1971 to determine the gonadotropin-releasing hormone (GnRH )structure. Later, the application of gel filtration, chromatographic separation and identification of purified hypothalamic hormones, no less than ten, each anterior pituitary hormone has at least one release factor or promote and inhibit two factors. Hypothalamus is the endocrine, behavioral and autonomic nerve center of integration, hypothalamic hormone refers to the hypothalamus produces endocrine activity of neuropeptides, by closely linked with pituitary regulation of endocrine function, and as a neurotransmitter, neuromodulator Cerebral cortex and limbic system play an influential role. Second, the hypothalamic hormone production and distribution: the hypothalamus is known to have peptide hormone synthetase and GnRH, TRH degradation