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目的探讨结直肠癌卵巢转移的外科治疗及影响患者预后的因素。方法搜集67例结直肠癌卵巢转移患者的资料,预后影响因素的单因素分析采用Log rank检验,多因素分析应用Cox比例风险模型进行回归分析。结果单侧卵巢转移、单纯卵巢转移、肿瘤转移仅限于盆腔内者多行根治性切除。全组67例结直肠癌卵巢转移患者总的1、3、5年生存率分别为71.0%、18.7%和9.2%。单因素分析结果显示,单纯卵巢转移、转移灶局限于盆腔内、单侧或双侧转移、手术方式是影响结直肠癌卵巢转移患者预后的主要因素(P<0.05)。多因素分析结果显示,仅手术方式是结直肠癌卵巢转移患者预后的独立影响因素(OR=3.531,P<0.001)。结论结直肠癌卵巢转移应行积极的外科治疗,争取根治性切除,有助于延长患者的生存时间。
Objective To investigate the surgical treatment of ovarian metastasis of colorectal cancer and the factors affecting the prognosis of patients. Methods The data of 67 patients with ovarian metastasis of colorectal cancer were collected. The univariate analysis of the prognostic factors was conducted by log rank test. The multivariate analysis was performed by Cox proportional hazards model. Results Unilateral ovarian metastasis, simple ovarian metastasis, tumor metastasis limited to pelvic multi-line radical resection. The overall 1, 3, 5-year survival rates of 67 patients with colorectal cancer with ovarian metastasis were 71.0%, 18.7% and 9.2%, respectively. Univariate analysis showed that simple ovarian metastasis and metastasis were limited to pelvic and unilateral or bilateral metastasis. The surgical method was the main factor affecting the prognosis of patients with ovarian metastasis of colorectal cancer (P <0.05). Multivariate analysis showed that the only operative method was independent prognostic factor of colorectal cancer patients with ovarian metastasis (OR = 3.531, P <0.001). Conclusion Colorectal cancer ovarian metastasis should be actively treated surgically, for radical resection, helps to extend the patient’s survival time.