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目的:探讨格列美脲在老年糖尿病中的应用。方法:选取在我院进行住院治疗的老年糖尿病患者共800例,随机分为研究组450例,对照组350例。对照组给予优泌林70/30、进行治疗,研究组在对照组治疗的基础上应用格列美脲进行治疗。结果:治疗后,两组患者的HbA1c、PBG、FBG、胰岛素用量均较治疗前有明显下降(P<0.05);BMI均比治疗前有所增加,但无显著性差异(P>0.05)。其中,除治疗后胰岛素用量研究组减少量明显少于对照组(P<0.05),两组间HbA1c、PBG、FBG三项指标比较,均无显著性差异(P>0.05)。在治疗过程中,对照组与研究组的低血糖发生率分别为16.86%、15.56%,经比较无显著性差异(P>0.05)。结论:选用格列美脲治疗老年糖尿病,可以有效改善血糖,控制低血糖反应发生,减少胰岛素用量,疗效显著,值得推广应用。
Objective: To investigate the application of glimepiride in senile diabetes mellitus. Methods: A total of 800 elderly patients with diabetes who were hospitalized in our hospital were randomly divided into study group (450 cases) and control group (350 cases). The control group received Euclidean 70/30 for treatment, and the study group was treated with glimepiride on the basis of the control group. Results: After treatment, the levels of HbA1c, PBG, FBG and insulin in both groups were significantly lower than those before treatment (P <0.05); BMI was increased compared with that before treatment, but there was no significant difference (P> 0.05). Among them, there was no significant difference in HbA1c, PBG and FBG between the two groups except the reduction of insulin dosage after treatment (P <0.05). In the course of treatment, the incidence of hypoglycemia in control group and study group were 16.86% and 15.56%, respectively, no significant difference (P> 0.05). Conclusion: The use of glimepiride in the treatment of senile diabetes mellitus can effectively improve blood sugar, control the occurrence of hypoglycemia and reduce the dosage of insulin, which has a significant curative effect and is worth popularizing and applying.