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目的探讨子宫颈鳞癌组织中LATS2的表达情况及临床意义。方法采用免疫组化SP法检测20例正常宫颈组织和40例子宫颈鳞癌组织中LATS2的表达情况,分析其表达情况与宫颈鳞癌之间的关系。结果 LATS2在宫颈鳞癌中的细胞核表达明显低于正常宫颈上皮(P<0.05);LATS2的表达降低与患者的肿瘤大小及有无淋巴结转移明显相关(P<0.05)。结论 LATS2在宫颈鳞癌中表达降低,其异常表达可能参与了宫颈鳞癌的发生发展。
Objective To investigate the expression of LATS2 in cervical squamous cell carcinoma and its clinical significance. Methods Immunohistochemical SP method was used to detect the expression of LATS2 in 20 cases of normal cervical tissue and 40 cases of cervical squamous cell carcinoma, and its relationship with cervical squamous cell carcinoma was analyzed. Results The nuclear expression of LATS2 in cervical squamous cell carcinoma was significantly lower than that in normal cervical epithelium (P <0.05). The decreased expression of LATS2 was significantly associated with tumor size and lymph node metastasis (P <0.05). Conclusion The expression of LATS2 is down-regulated in cervical squamous cell carcinoma, which may be involved in the occurrence and development of cervical squamous cell carcinoma.