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目的 评价血清SA、CP_2、CA_(125)在子宫内膜癌诊断及判断预后中的意义。方法 测定43例子宫内膜癌病人和30例对照正常女性静脉血清SA、CP_2、CA_(125)值,并分析其与疾病分期、细胞分化、瘤组织侵肌、腹水癌细胞阳性和淋巴结转移等预后因素之间的关系。结果 在子宫内膜癌病人中,SA灵敏度和特异度分别为24/43(55.81％)、26/30(86.67％);CP_2为22/43(51.16％)、29/30(96.67％);CA_(125)为9/43(20.93％)、30/30(100％)。CP_2升高程度与瘤组织侵肌正相关;CA_(125)升高程度与瘤细胞分化、病人分期正相关。联合3项指标检测,灵敏度和特异度可达81.39％、83.33％。结论 SA、CP_2单项检测子宫内膜癌灵敏度高于CA_(125);并且CP_2与CA_(125)升高程度将影响病人的预后;联合多项指标检测有可能优于单项。
Objective To evaluate the significance of serum SA,CP_2 and CA_(125) in the diagnosis and prognosis of endometrial carcinoma. Methods Serum levels of SA, CP_2, and CA_(125) in 43 patients with endometrial carcinoma and 30 normal controls were measured. The serum levels of SA, CP_2, and CA_(125) were analyzed and analyzed for disease staging, cell differentiation, invasion of tumor tissue, ascites cancer cells, and lymph node metastasis. The relationship between prognostic factors. Results In patients with endometrial cancer, the sensitivity and specificity of SA were 24/43 (55.81%) and 26/30 (86.67%) respectively; CP_2 was 22/43 (51.16%) and 29/30 (96.67%). The CA_(125) is 9/43 (20.93%) and 30/30 (100%). The degree of CP_2 elevation was positively correlated with the invasiveness of tumor tissue; the elevation of CA_(125) was positively correlated with tumor cell differentiation and patient staging. Combined detection of three indicators, the sensitivity and specificity of up to 81.39%, 83.33%. Conclusions The sensitivity of SA and CP_2 in the detection of endometrial cancer is higher than that of CA_(125). The increase of the level of CP_2 and CA_125 will affect the prognosis of patients. Joint detection of multiple indicators may be better than single.