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目的探讨妊娠期高血压疾病(HDCP)患者血清胱抑素C(Cys-C)和尿微量白蛋白(UmAlb)联合检测的临床价值。方法选择HDCP患者143例,其中,妊娠期高血压68例,轻度子痫前期43例,重度子痫前期32例。另选择同期在本院产前体检的30例正常孕妇作为对照组。分别采血及尿液检测血Cys-C、尿素氮(BUN)、肌酐(Scr)和UmAlb水平并进行比较分析。结果妊娠期高血压组、轻度子痫前期组、重度子痫前期组三组患者血清Cys-C及UmAlb水平均显著高于对照组(P均<0.01);妊娠期高血压组、轻度子痫前期组、重度子痫前期组三组间Cys-C和UmAlb水平比较,差异均有统计学意义(妊娠期高血压组<轻度子痫前期组<重度子痫前期组,P均<0.01)。重度子痫前期组血BUN和Scr水平均明显高于对照组(P<0.01),而妊娠期高血压组、轻度子痫前期组血BUN、Scr水平与对照组比较,差异均无统计学意义(P均>0.05)。结论血清Cys-C和UmAlb均为反映HDCP患者早期肾功能损害的敏感指标,两者联合检测对HDCP早期肾损害的诊断有重要价值。
Objective To investigate the clinical value of combined detection of serum cystatin C (Cys-C) and urinary microalbumin (UmAlb) in patients with gestational hypertension (HDCP). Methods 143 patients with HDCP were selected, including 68 cases of gestational hypertension, 43 cases of mild preeclampsia and 32 cases of severe preeclampsia. In the same period, 30 normal pregnant women who took prenatal examination during the same period were selected as the control group. Cys-C, BUN, Scr and UmAlb levels in blood and urine were measured and compared. Results The levels of serum Cys-C and UmAlb in hypertensive pregnancy group, mild preeclampsia group and severe preeclampsia group were significantly higher than those in the control group (all P <0.01). The gestational hypertension group, mild The levels of Cys-C and UmAlb in the three groups of preeclampsia group and severe preeclampsia group were significantly different (P <0.01 in gestational hypertension group 0.05). Conclusions Serum Cys-C and UmAlb are sensitive indicators of early renal impairment in patients with HDCP. Combined detection of these two markers is of great value in the diagnosis of HDCP early renal damage.