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目的:考察铁帚清浊丸对前列腺增生的影响及抗炎免疫作用。方法:给去势大鼠皮下注射丙酸睾酮诱导形成前列腺增生模型,观察铁帚清浊丸对抗前列腺增生的作用。大鼠足跖浮肿法、大鼠棉球植入法和小鼠耳肿胀法观察铁帚清浊丸的抗炎作用;小鼠碳粒廓清法和溶血素测定法观察铁帚清浊丸对免疫功能的调节作用。结果:铁帚清浊丸能显著抑制丙酸睾酮诱导去势大鼠前列腺的增生,降低前列腺指数的增加(P<0.05);显著抑制大鼠棉球肉芽肿增生、角叉菜胶致大鼠的足肿和二甲苯致小鼠的耳肿(P<0.05,P<0.01);显著提高小鼠HC50和碳末廓清指数(P<0.05)。结论:铁帚清浊丸具有抗炎,提高免疫力及抑制前列腺增生的作用。
OBJECTIVE: To investigate the effect of Tieshu Qingzhuo Pill on benign prostatic hyperplasia and its anti-inflammatory and immunological effects. Method: Subcutaneous injection of testosterone propionate induces formation of benign prostatic hyperplasia model in ovariectomized rats, and observes the effect of Tieshu Qingzhuo Pill on prostatic hyperplasia. Rat paw edema method, rat cotton ball implants and mouse ear swelling method to observe the anti-inflammatory effect of iron broom Qingzhuo pill; carbon clearance method and hemolysin assay mice observed iron broom Qingzhuo Wan immune Function of the regulatory role. Results: Tiebacaozhao Pill could significantly inhibit the proliferation of testosterone-induced ovariectomized rats and reduce the increase of prostate index (P <0.05), and significantly inhibit the proliferation of rat granuloma caused by carrageenan (P <0.05, P <0.01); significantly increased HC50 and carbon clearance index (P <0.05) in mice. Conclusion: Tiewang Qingzhuo Wan has the effects of anti-inflammation, enhancing immunity and inhibiting the proliferation of benign prostatic hyperplasia.