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本文用放射免疫分析法(RIA),测定了30例正常人及46例慢性肾脏疾病患者血浆心钠素(ANF)水平,并对其中12例尿毒症患者(HD4例,CAPD8例)透析前后血浆心钠素含量的变化进行了观察。结果表明,肾衰患者血浆心钠素水平明显增高(p<0.05);血心钠素水平与Scr密切相关(α=0.6482,p<0.05);尿毒症合并高血压者血心钠素明显高于无高血压者(p<0.05);透析后血心钠素水平明显下降(p<0.05)。
Radioimmunoassay (RIA) was used to determine plasma atrial natriuretic peptide (ANF) in 30 normal subjects and 46 patients with chronic kidney disease. The plasma levels of ANP in 12 patients with uremia (HD4, CAPD8) Changes in atrial natriuretic peptide were observed. The results showed that plasma atrial natriuretic peptide levels were significantly increased in patients with renal failure (p <0.05); blood atrial natriuretic peptide level was closely related to Scr (α = 0.6482, p <0.05); serum atrial natriuretic peptide was significantly higher in uremic patients with hypertension In patients without hypertension (p <0.05), serum atrial natriuretic peptide decreased significantly after dialysis (p <0.05).