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[目的]探讨P-糖蛋白在溃疡性结肠炎(UC)患者肠黏膜中表达的水平及意义。[方法]以健康体检者作为对照组,对来自45例UC患者60份肠黏膜应用免疫组织化学的方法检测P-糖蛋白的表达。[结果]P-糖蛋白在UC肠黏膜的表达水平与疾病本身及疾病的病情轻重、疾病是否活动无直接相关性,但与是否为难治性UC有关。难治性UC患者的肠黏膜中P-糖蛋白表达水平较非难治性UC患者低(P<0.05),但经治疗病情缓解后P-糖蛋白在肠黏膜的表达水平有显著提升(P<0.05),与正常对照组比较差异无统计学意义。[结论]P-糖蛋白在难治性UC肠黏膜的表达降低,可能构成疾病难治的原因之一。中药治疗难治性UC有效的机制可能通过上调P-糖蛋白在肠黏膜中的表达而修复肠黏膜屏障功能来实现。
[Objective] To investigate the expression and significance of P-glycoprotein in intestinal mucosa of patients with ulcerative colitis (UC). [Methods] With healthy subjects as the control group, 60 cases of intestinal mucosa from 45 UC patients were examined for the expression of P-glycoprotein using immunohistochemistry. [Results] The expression level of P-glycoprotein in UC intestinal mucosa was not related to the severity of the disease itself and the disease, whether the disease was active or not, but whether it was refractory UC. The expression of P-glycoprotein in intestinal mucosa of patients with refractory UC was lower than that of patients with non-refractory UC (P <0.05), but the expression of P-glycoprotein in the intestinal mucosa significantly increased after treatment (P < 0.05), no significant difference compared with the normal control group. [Conclusion] The decreased expression of P-glycoprotein in refractory UC intestinal mucosa may be one of the reasons for refractory disease. Traditional Chinese medicine treatment of refractory UC effective mechanism may be through the up-regulation of P-glycoprotein in the intestinal mucosa expression and repair of intestinal mucosal barrier function to achieve.