目的　探讨白花蛇舌草在可移植性人脑胶质瘤间质化疗的剂量及疗效 ,并探讨其作用机制。方法　将低分化人脑胶质瘤体外细胞系SHG 4 4移植于裸小鼠 ,制作成可移植性实体瘤模型 ,用不同剂量的白花蛇舌草及以博莱霉素为对照组 ,肿瘤间质内注射药物 ,观察实体瘤的瘤重及组织细胞形态的变化。结果　将白花蛇舌草每 1ml含总黄酮以芦丁计算不少于 0 2 5mg时 ,每日 1次 ,间质注射 0 5ml持续 12日后 ,肿瘤生长有明显抑制作用 (P <0 0 5 )。结论　白花蛇舌草有明显抑制肿瘤生长的作用。 Objective To investigate the dose and therapeutic effect of Hedyotis diffusa Willd on transplanted human glioma mesenchymal stem cells and its mechanism of action. Methods Human glioma cell line SHG 4 4 was transplanted in nude mice and made into a solid tumor transplantable model. With different doses of Hedyotis diffusa and bleomycin as the control group, Intraperitoneal injection of drugs, observe the solid tumor weight and histological changes. Results The content of total flavonoids in Hedyotic diffusa will not increase more than 0 2 5 mg per 1 ml of rutin, once daily and 0 5 ml of interstitial injection for 12 days, the tumor growth was significantly inhibited (P <0.05) . Conclusion Hedyotis diffusa will obviously inhibit tumor growth.