一、前言 2,3-苯骈-1-硫-4-氮-5,7-二取代(或5,7,7-三取代)-4,5,6,7-四氢化硫氮杂(艹卓)(简称四氢化苯骈杂(艹卓))和6,7-二氢化硫氮杂(艹卓)(简称二氢化苯骈杂(艹卓))是治疗神经系统疾病的药物。我们对七个四氢化苯骈杂(艹卓)和六个二氢化苯骈杂(艹卓)进行核磁波谱研究。这类化合物的七元杂环内含有一个或二个不对称碳。手性碳的存在导致其相邻的-CH_2-上二个氢磁不等同,形成了原手性基团,使谱线裂分。通过双共振技术(同核去偶、INDOR)和计算机自旋模拟等技术着重研究七元杂 I. INTRODUCTION OF 2,3-BENZO-1-SULFIDE-4-NAPHTHYL-5,7-DISUBSTITUTED (OR 5,7,7-TRITTEDS) -4,5,6,7- (Referred to as tetrahydrobenzofuran) and 6,7-dihydrothiazepine (benzhydryl) are drugs for the treatment of nervous system diseases. We conducted seven nuclear magnetic resonance spectroscopy studies on seven phenylbenzimidazoles and six phenylbenzimidazoles. Seven-membered heterocycles of such compounds contain one or two asymmetric carbons. The presence of chiral carbon leads to the two hydrogen adjacent to the -CH2- is not equal, forming the original chiral group, the spectral line split. Through the double resonance technology (co-nuclear to dual, INDOR) and computer spin simulation and other techniques focused on seven yuan