1概述自从在慢性髓细胞型白血病细胞中发现Philade-phia染色体(PH染色体)以来,发现和报道的融合基因大多数是关于白血病以及恶性淋巴瘤的。随着分子生物学技术的发展,近年在实体瘤中也发现了许多有特异性的染色体易位,特别是在一些起源于中胚层的软组织肿瘤[1]。染色体易位以后 1 Overview Since the discovery of the Philade-phia chromosome (PH chromosome) in chronic myeloid leukemia cells, most of the fusion genes discovered and reported are related to leukemias and malignant lymphomas. With the development of molecular biology techniques, many specific chromosomal translocations have also been found in solid tumors in recent years, especially in some of the soft tissue tumors that originate from the mesoderm [1]. Chromosomal translocation later