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目的:探讨肝硬化患者血清肝纤维化指标与肝硬化病变程度及血脂水平的相关性。方法:测定肝硬化患者血脂水平及血清肝纤维化指标。结果:随着临床肝硬化程度的加重,血清肝纤维化指标逐渐增高。胆固醇逐渐下降。肝硬化患者血脂水平与LN呈正相关(P<0.05),而与HPCⅢ无明显相关(P>0.05)。在Child-pugh分级C级患者中,胆固醇与HA、IV-C呈负相关(P<0.05)。结论:肝硬化时血脂与肝纤维有一定相关性。联合检测HA、HPCⅢ、IV-C、LN及血脂对估测肝硬化的严重程度及预后有一定临床价值。
Objective: To investigate the correlation between serum levels of hepatic fibrosis and the severity of cirrhosis and serum lipids in cirrhotic patients. Methods: The levels of serum lipids and serum liver fibrosis in patients with cirrhosis were measured. Results: With the increasing degree of clinical cirrhosis, serum liver fibrosis index increased gradually. Cholesterol gradually decreased. There was a positive correlation between serum lipids and LN in patients with cirrhosis (P <0.05), but no significant correlation with HPC (P> 0.05). Cholesterol was negatively correlated with HA and IV-C in Child-pugh class C patients (P <0.05). Conclusion: There is a certain correlation between serum lipids and liver fibrosis during cirrhosis. Joint detection of HA, HPCⅢ, IV-C, LN and blood lipid have some clinical value in estimating the severity and prognosis of liver cirrhosis.