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问:α-肾上腺能受体阻滞剂分几类? 答:具有α-肾上腺素能受体阻滞作用的常用药物有酚妥拉明、苯氧苄胺、哌唑嗪、特拉唑嗪(Terazosin)、育亨宾(Yohimbine)、氯丙嗪、氟哌啶醇(Haloperidol)等。最近,Frishman等根据α-阻滞剂作用特点分为以下几种类型。 1.非选择性α-阻滞剂:这组药物对α_1受体和α_2受体均有阻滞作用,包括非竞争性阻滞剂苯氧苄胺和竞争性阻滞剂酚妥拉明。苯氧苄胺主要作用于α_1受体,其效力大于α_2受体30～100倍,但无临床意义,可用于高血压治疗。酚妥拉明还具有直接扩血管作用和对交感神经,副交感神经的作用,可用于高血压、高血压危象的治疗。但近几年来更倾向用于充血性心力衰竭的治疗。
Q: α-adrenergic receptor blocker divided into several categories? A: with α-adrenergic receptor blockade of the commonly used drugs are phentolamine, phenoxybenzamine, prazosin, terazosin Terazosin, Yohimbine, chlorpromazine, Haloperidol and the like. Recently, Frishman, etc. according to the characteristics of α-blocker is divided into the following types. 1. Non-selective α-blockers: This group of drugs on both α_1 receptor and α_2 receptor blockade, including the noncompetitive blocker phenoxybenzamine and the competitive blocker phentolamine. Phenoxybenzamine mainly acts on the alpha 1 receptor, its potency is greater than the alpha 2 receptor 30 to 100 times, but no clinical significance, can be used for the treatment of hypertension. Phentolamine also has a direct vasodilator effect on the sympathetic and parasympathetic effects, can be used for the treatment of hypertension, hypertension crisis. But in recent years more inclined to the treatment of congestive heart failure.