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目的：探讨不同致“阳虚”药物对雄大鼠骨代谢的影响。方法：实验用３月龄ＳＤ大鼠３２只，随机分为对照组（Ａ１）组１、对照组（Ａ２）组２、激素（Ｂ）组和羟基脲（Ｃ组），Ａ１和Ａ２组灌喂生理盐水１ｍｌ／ｋｇ，Ｂ组灌喂泼尼松４．５ｍｇ／ｋｇ，Ｃ组灌喂羟基脲０．２５ｇ／ｋｇ，每周３次，３个月后用图象分析仪对四组大鼠胫骨中段的骨片进行动态及静态测算和分析。结果：Ｂ组和Ｃ组分别与Ａ１组和Ｂ１组比较，都出现骨吸收大于骨形成，导致骨量丢失，从而出现皮质骨变薄，骨髓腔增大。结论：致“阳虚”药物泼尼松和羟基脲均可引起大鼠骨质疏松，但二者所造成骨量丢失的机理不尽相同。
Objective: To investigate the effects of different Yang-induced drugs on bone metabolism in male rats. Methods: Thirty-two SD rats of 3 months old were randomly divided into control group (A1), control group (A2), hormone group (B) and hydroxyurea group 1 ml / kg of normal saline was infused, Group B was fed with 4.5 mg / kg of prednisone, Group C was fed with 0.25 g / kg of hydroxyurea, 3 times a week. After 3 months, Rat bone fragments in the middle of the tibia dynamic and static measurement and analysis. Results: Compared with group A1 and group B1, group B and group C showed greater bone resorption than bone formation, resulting in loss of bone mass, resulting in cortical bone thinning and bone marrow cavity enlargement. CONCLUSION: Prednisone and hydroxyurea induced by “yang deficiency” can all induce osteoporosis in rats, but the mechanism of bone loss caused by both is not the same.