论文部分内容阅读
目的 :探讨输血患者产生不规则血型抗体的危险因素,为减少输血不良反应的发生,提供输血前不规则抗体筛查的依据。方法:4 200例进行回顾性分析。以不规则抗体阳性患者为病例组,不规则抗体阴性者为对照组,对两组进行比较,并对患者所属科室与抗体种类进行研究。结果:在4 200例中有20例患者检测出不规则抗体阳性,阳性率为0.48%;其中女15例,男5例。在女性患者中,孕妇11例(0.26%);妇产科患者不规则抗体检出率最高,但经连续性校正χ2检验表明各科室不规则抗体检出率之间无显著性差异(P>0.05)。不规则抗体特异性鉴定结果显示,以Rh血型系统居多,抗-E抗体占65.0%,抗-E抗体+抗-M占15.0%;Dufffy血型系统抗Fya-抗体占15.0%;未知抗体占5.0%。结论 :妊娠和反复输血是患者产生不规则抗体的危险因素;对患者进行输血前不规则抗体筛查,有助于提高配血的准确率,有效减少或避免输血不良反应的发生,提高输血治疗的安全性。
Objective: To explore the risk factors of irregular blood group antibody in transfusion patients and to provide basis for the screening of irregular antibody before transfusion in order to reduce the incidence of transfusion adverse reactions. Methods: 4 200 cases were retrospectively analyzed. Irregular antibody-positive patients as the case group, irregular antibody negative as the control group, the two groups were compared, and the patient belongs to the department and antibody types were studied. Results: In 4 200 cases, 20 cases of patients detected irregular antibody positive, the positive rate was 0.48%; 15 cases were female and 5 were male. In female patients, 11 pregnant women (0.26%) had the highest detection rate of irregular antibodies in obstetrics and gynecology patients. However, there was no significant difference in detection rate of irregular antibodies among different departments (P> 0.05). The results of irregular antibody-specific identification showed that the majority of Rh blood group systems were anti-E antibody, anti-E antibody and anti-M accounted for 65.0%, Dufffy blood system anti-Fya antibody 15.0% and unknown antibody 5.0% %. Conclusion: Pregnancy and repeated blood transfusions are risk factors for patients with irregular antibodies. Screening of patients with irregular antibodies prior to transfusion may improve the accuracy of blood distribution, reduce or avoid adverse transfusion reactions, and improve transfusion therapy Security.