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研究了环孢霉素Ａ（ＣｓＡ）、环磷酰胺（ＣＴＸ）及甲基强的松龙（ＭＰ）对大鼠单个核细胞（ＭＮＬ）雄激素体（ＡＲ）及雌激素受体（ＥＲ）的影响，结果表明：静注ＣｓＡ２０ｍｇ／ｋｇ，ＥＲ明显降低，３ｈ作用这高峰，持续低水平达８ｈ；而ＡＲ无明显影响．静注ＣｓＡ１００ｍｇ／ｋｇ用ＣＴＸ和ＭＰ使ＡＲ、ＥＲ均明显降低，而ＣＴＸ和ＭＰ使ＥＲ降低，也使ＡＲ降低，故ＣｓＡ免疫抑制作用优于ＣＴＸ和ＭＲ。ｐ＜０．０１二、ＣｓＡ作用剂量──效应关系根据ＣｓＡ大鼠实验的无效浓度（＜１０ｍｇ／ｋｇ），有效浓度（２０ｍｇ／ｋｇ），急性肾毒浓度（５０ｍｇ／ｋｇ）和更高浓度（１００ｍｇ／ｋｇ）分为４组，４组５次实验结果见表２。表２不同浓度ＣｓＡ对ＭＮＬ的ＥＲ和ＡＲ影响注：与对照用比，＊ｐ＜０．０５，ｐ＜０．０１从表２可见，５ｍｇ时对ＥＲ和ＡＲ无影响；２０ｍｇ时使ＥＲ降低５０％左右，与对照组差异非常显著（ｐ＜０．０１）；５０和１００ｍｇ时降低更明显；２０ｍｇ时ＡＲ轻度降低，但与对照组差异不显著（ｐ＞０．０５）。５０和１００ｍｇ时ＡＲ则明显降低。三、不同免疫抑制剂对ＥＲ和ＡＲ的影响ＣｓＡ、ＣＩＸ、ＭＰ及三药联合组５次实验结果见表３。从表３可见，用Ｃ?
The effects of cyclosporin A (CsA), cyclophosphamide (CTX) and methylprednisolone (MP) on androgen receptor (AR) and estrogen receptor (ER) in rat mononuclear cells (MNL) The results showed that: the intravenous injection CsA20mg / kg, ER decreased significantly, 3h effect peak, continued low level up to 8h; and AR no significant effect. Intravenous injection of CsA at 100 mg / kg significantly reduced AR and ER with CTX and MP, while CTX and MP decreased ER and AR, indicating that immunosupression of CsA was superior to CTX and MR. p <0.01 2. CsA dose-effect relationship According to the CsA rat experimental invalid concentration (<10mg / kg), effective concentration (20mg / kg), acute renal toxicity (50mg / kg) and higher concentration (100mg / kg) divided into 4 groups, 4 groups of 5 times the experimental results in Table 2. Table 2 Effect of Different Concentrations of CsA on ER and AR in MNLs Note: Compared to controls, * p <0.05, p <0.01 As can be seen from Table 2, there was no effect on ER and AR at 5 mg; ER decreased at 20 mg (P <0.01). The decrease was more pronounced at 50 and 100 mg. AR was slightly decreased at 20 mg but not significantly different from the control group (p> 0.05). AR was significantly lower at 50 and 100 mg. Third, the different immunosuppressive agents on ER and AR CsA, CIX, MP and three drug combination group 5 times the experimental results in Table 3. Can be seen from Table 3, with C?