Purpose: The aim of this study was to evaluate routine ophthalmic data to iden tify clinically useful risk factors for progressive visual field loss in patient swith primary open-angle glaucoma (POAG) already receiving intraocular pressure -lowering treatments. Methods: A retrospective cohort study design was used. Ro utine ophthalmic data for all subjects were obtained from case records with the knowledge that baseline clinical data had been collected in a standardised manne r. Progression was defined according to the AGIS visual field defect scoring sys tem. Variables evaluated as candidate risk factors for progression were assessed by survival analysis. Factors exerting a significant effect on survival were su bsequently tested in a Cox proportional hazards model. Results: A cohort of 108 eligible POAG patients was followed over an average of 3.6 years, with an averag e visual field intertest interval of 8months. The incidence rate of progressive loss among the cohort was 5.4 cases per 100 person years. Increasing age was fou nd to be independently associated with a small but significantly increased risk of glaucomatous visual field defect progression (hazard ratio 1.07, P=0.022), an d a borderline association was also demonstrated with being male (hazard ratio 2 .76, P=0.057). Conclusions: This retrospective investigation has provided prelim inary information on factors associated with increased risk of progressive glauc omatous visual field loss that may inform clinical care strategies. Lack of conc ordance with other studies suggests that further prospective investigations are needed if risk stratification strategies are to be employed in caring for patien ts with chronic open-angle glaucoma. Purpose: The aim of this study was to evaluate routine ophthalmic data to iden tify clinically useful risk factors for progressive visual field loss in patient swith primary open-angle glaucoma (POAG) already receiving intraocular pressure -lowering treatments. Methods: A retrospective cohort study design was used. Ro utine ophthalmic data for all subjects were obtained from case records with the knowledge that baseline clinical data had been collected in a standardized manner. Progression was defined according to the AGIS visual field defect scoring sys tem. Risk factors for progression were assessed by survival analysis. Factors exert a significant effect on survival were su bicide tested in a Cox proportional hazards model. Results: A cohort of 108 eligible POAG patients was over an average of 3.6 years, with an averag e visual field intertest interval of 8months. The incidence rate of progressive loss among the cohort was 5.4 cases per 100 person years. Increasing age was fou nd to be independently associated with a small but significantly increased risk of glaucomatous visual field defect progression (hazard ratio 1.07, P = 0.022), an da borderline association was also demonstrated with being male (hazard ratio 2.76, P = 0.057). Conclusions: This retrospective investigation has provided preliminary information on factors associated with increased risk of progressive glauc omatous visual field loss that may inform clinical care strategies. Lack of conc ordance with other studies suggests that further prospective investigations are needed if risk stratification strategies are to be employed in caring for patien ts with chronic open-angle glaucoma.