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[目的]实验观察补益脾肾中药对阿霉素注射液造模大鼠的一般状态的改善作用,并与养血活血中药对照。[方法]用阿霉素注射液给大鼠尾静脉注射6.5mg/kg,造模大鼠分成黄芪汤(黄芪、党参、附子、肉桂、白术、茯苓、泽泻、炙甘草)预防组、黄芪汤治疗组、养血活血组(当归、丹参、赤芍)、致病对照组(造模后未治疗)、空白对照组:未造型。观察体重及一般状态如饮食,大便、水肿、精神状态,活动,皮毛等症状的变化,共8周。[结果]阿霉素注射液造模大鼠呈现脾肾阳虚特征。黄芪汤预防组及治疗组治疗造模大鼠时,其大鼠腹泻轻微、饮食不振恢复快,畏寒、少动,精神萎靡,皮毛不泽,阴囊水肿等症状也较快得到改善,体重增长明显优于养血活血组及致病对照组;养血活血组的症状改善较差,食欲不振明显,体重降低,体重增长明显低于致病对照组。[结论]辨证施治实验大鼠,可以改善阿霉素所致的毒副作用。
[Objective] To observe the effect of replenishing spleen-kidney traditional Chinese medicine on the general state of adriamycin-injection model rats, and compare it with nourishing and promoting blood-activating traditional Chinese medicine. [Methods] Doxorubicin injection was used to inject 6.5 mg/kg into the tail vein of rats. The model rats were divided into the prevention group of Huangqi Decoction (Astragalus, Codonopsis, Aconite, cinnamon, Atractylodes macrocephala, Atractylodes Rhizome, Alisma, Zhigancao), and Astragalus membranaceus. Soup treatment group, nourishing blood circulation group (Danggui, Salvia miltiorrhiza, red peony), pathogenic control group (untreated after modeling), blank control group: not styling. Observe changes in body weight and general conditions such as diet, stool, edema, mental status, activity, and fur, for a total of 8 weeks. [Results] The rats modeled by adriamycin injection showed the characteristics of spleen and kidney Yang deficiency. When the Huangqi Decoction prophylaxis and treatment group were used to treat model rats, the rats had mild diarrhea, poor diet recovery, chills, lack of movement, apathetic, skinless, and scrotal edema. The symptoms were also improved quickly. Significantly better than nourishing and activating blood group and pathogenic control group; nourishing and activating blood group had poorer symptoms, less appetite, lower body weight, and lower weight gain than the pathogenic control group. [Conclusion] Syndrome treatment of experimental rats can improve the toxic side effects caused by doxorubicin.