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目的:探讨糖化血清白蛋白(glycate dalbumin,GA)作为反映近期(2周内)血糖控制总体水平的指标在糖尿病人群中的临床应用价值。方法:选取2010年6月-2013年7月间深圳市福田区中医院住院的2型糖尿病(T2DM)患者323例,测定空腹血糖(FPG)、餐后2小时血糖(2hPG)、1日指尖血糖谱均值(MBG)、GA、糖化血红蛋白(HbAlc)等,并对其中92例住院近2周的患者分别在入院后6天及12天复查上述指标。结果:GA与HbAlc(r=0.791),FPG(r=0.541),2hPG(r=0.456),MBG(r=0.401),均呈正相关(P均<0.01);患者入院6天检测GA为(27.1±5.45)%,入院12天为(22.77±4.34)%,均显著低于入院第一天的(30.31±6.75)%(P<0.01);入院6天和12天,患者的GA较入院时分别下降3.12%和7.54%(P<0.01);HbAlC分别下降0.31%和0.78%,GA下降降幅显著大于HbAlc(P<0.01)。结论:GA可及时、准确的反映短期(1~2周)平均血糖的变化情况,并与长期血糖控制的金标准HbAlC有良好的相关性,是监测糖尿病患者血糖控制的良好指标。
Objective: To investigate the clinical value of glycated dalbumin (GA) as an indicator of the overall level of glycemic control in the recent (within 2 weeks) diabetic population. Methods: 323 patients with type 2 diabetes mellitus (T2DM) hospitalized in Futian District Hospital of Traditional Chinese Medicine from June 2010 to July 2013 were enrolled in this study. Fasting blood glucose (FPG), postprandial 2-hour blood glucose (2hPG) MBG, GA, HbAlc and so on, and 92 of them were hospitalized for nearly 2 weeks, and the indexes were respectively examined on the 6th and 12th days after admission. Results: GA had a positive correlation with HbAlc (r = 0.791), FPG (r = 0.541), 2hPG (r = 0.456) and MBG (r = 0.401) 27.1 ± 5.45)%, 12.7 days after admission (22.77 ± 4.34)%, which were significantly lower than those on the first day of hospital admission (30.31 ± 6.75)% (P <0.01) (P <0.01). HbAlC decreased by 0.31% and 0.78% respectively, while the decrease and decrease of GA in HbAlc were significantly greater than those in HbAlc (P <0.01). Conclusion: GA can reflect the short-term (1-2 weeks) average blood glucose changes in a timely and accurate manner and has a good correlation with the long-term blood glucose control standard HbAlC, which is a good indicator of glycemic control in diabetic patients.