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δ阿片受体属G蛋白偶联受体 ,其配体可抑制细胞内环磷酸腺苷水平和调节电压依赖的钙离子通道和钾离子通道。最近研究还发现 ,δ阿片受体选择性配体可介导细胞内储存钙的释放 ,并且调节各种蛋白激酶。本文就δ阿片受体的信号转导途径的研究进展进行综述。
δ opioid receptor is a G protein-coupled receptor whose ligand inhibits intracellular cyclic AMP levels and regulates voltage-dependent calcium and potassium channels. Recent studies have also found that δ opioid receptor-selective ligands mediate the release of intracellular calcium stores and regulate various protein kinases. This article reviews the progress of the signal transduction pathway of δ opioid receptors.