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目的探讨补体C4基因多态性与中国汉族儿童过敏性紫癜(HSP)的关系。方法 HSP汉族儿童188例(HSP组)分为肾炎组(74例,合并紫癜性肾炎)和无肾炎组(114例,无肾炎)。健康汉族儿童130例为对照组。ELISA法检测HSP组血清补体C4水平。结果 HSP组C4AQ0频率高于对照组(7.98%vs.0.77%)(P<0.01)。肾炎组与无肾炎组的C4AQ0频率相仿(8.11%vs.7.89%)(P>0.05)。HSP组和对照组均无C4BQ0。HSP患儿中,C4AQ0患儿血清补体C4水平低于无C4AQ0者[(0.216±0.045)g/L vs.(0.262±0.064)g/L](P<0.05)。结论补体C4基因多态性与汉族儿童HSP的发生有关,提示C4AQ0可能是汉族儿童HSP的易感基因。
Objective To investigate the relationship between complement C4 gene polymorphism and Henoch-Schonlein purpura (HSP) in Chinese Han children. Methods 188 cases of HSP Han children (HSP group) were divided into nephritis group (74 cases, with purpuric nephritis) and no nephritis group (114 cases, no nephritis). 130 healthy Han children as the control group. Serum complement C4 level in HSP group was detected by ELISA. Results The frequency of C4AQ0 in HSP group was higher than that in control group (7.98% vs.0.77%) (P <0.01). The frequency of C4AQ0 in nephritis group was similar to that in nephritis group (8.11% vs.7.89%) (P> 0.05). None of the HSP and control groups had C4BQ0. In children with HSP, the levels of serum complement C4 in children with C4AQ0 were lower than those without C4AQ0 [(0.216 ± 0.045) g / L vs. (0.262 ± 0.064) g / L] (P <0.05). Conclusion Complement C4 gene polymorphism is associated with the occurrence of HSP in Han children, suggesting that C4AQ0 may be a susceptibility gene of HSP in Han children.