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研究细胞免疫功能与非小细胞肺癌（ＮＳＣＬＣ唯手术综合治疗预后的关系。从１９９２年１月至１９９４年１２月，对２６６例接受放疗和化疗综合治疗的非小细胞肺癌患者检测周围血Ｔ淋巴细胞亚群，经４年随访，采用Ｋａｐｌａｎ—Ｍｅｉｅｒ生存曲线经Ｌｏｇ—ｒａｎｋ检验，比较细胞免疫功能尚好组（Ｔ４／Ｔ８≥１）与较差组（Ｔ４／Ｔ８＜１）患者的 １年、２年和３年肿瘤局部控制率、无远处转移率和生存率。结果：非小细胞肺癌患者的细胞免疫功能较正常人明显低下（＜０．０１）；Ｔ４／Ｔ８≥ｌ和Ｔ４／Ｔ８＜ｌ两组的肿瘤局控率无明显差异（Ｐ＝０．２４５）；但前者的肿瘤无远处转移率和生存率显著优于后者（Ｐ＝０．００９和Ｐ＝０．００５）。结论：细胞免疫状态对非小细胞肺癌的治疗效果密切相关，良好的免疫功能可能通过抑制肿瘤的远处转移而提高患者的生存率。
To study the relationship between cellular immune function and prognosis of non-small cell lung cancer (NSCLC). From January 1992 to December 1994, 266 patients with non-small cell lung cancer treated with combined radiotherapy and chemotherapy were tested for peripheral blood T lymphocytes. After 4 years of follow-up, the subpopulations of cells were subjected to Log-rank test using the Kaplan-Meier survival curve. One year of patients with good cellular immune function (T4/T8 ≥ 1) and poorer (T4/T8 <1) groups were compared. Local control rate, no distant metastasis rate, and survival rate in 2 years and 3 years.Results: The cellular immune function of NSCLC patients was significantly lower than that of normal people (<0.01);T4/T8≥l and T4/ There was no significant difference in tumor localization rate between the two groups (P=0.245). However, the distant metastases and survival rates of tumors in the former group were significantly better than the latter (P=0.009 and P=0.005). Conclusion: Cellular immune status is closely related to the therapeutic effect of non-small cell lung cancer, good immune function It is possible to increase the patient’s survival rate by inhibiting the distant metastasis of the tumor.