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为控制甲型肝炎的流行，我们于1990年以株州市某厂子弟学校7-10岁的学生为对象进行H2减毒活疫苗人体免疫后血清学动态的研究。接种组为851人，对照组349人。免疫后分别于1、3、6、12、24个月采血检测ALT均正常，抗HAV抗体阳转率分别为91．80％、100％、99．45％、93．00％和88％；GMRT分别为10．64、14．59、6．42、6．31和3．49。其抗HAV抗体与野毒株甲型肝炎病毒隐性感染者的抗HAV抗体水平相类似。未发现异常反应。从本次研究结果表明应用H2减毒活疫苗进行人体免疫是安全有效的，易感人群接冲甲型肝炎减毒活疫苗可作为控制甲型肝炎流行的重要措施之一。
In order to control the spread of hepatitis A, we studied the serological dynamics of human live attenuated H2 live attenuated vaccine in 1990 to 7-10-year-old students of a factory in Zhuzhou. There were 851 inoculation groups and 349 in control group. The ALT levels were all normal at 1, 3, 6, 12 and 24 months after immunization. The positive rates of anti - HAV antibody were 91.80%, 100%, 99.45%, 93.00% and 88% respectively. GMRT were 10.64, 14.59, 6.42, 6.31 and 3.49 respectively. Its anti-HAV antibody is similar to that of wild-type Hepatitis A virus. No abnormal reaction was found. From the results of this study shows that the application of live attenuated H2 vaccine to human body is safe and effective, and susceptible population of live attenuated attenuated hepatitis A vaccine can be used as one of the important measures to control the spread of hepatitis A.