妊娠期肝脏胆汁郁积症又称妊娠特发性黄疸或妊娠复发性黄疸。本病始由Ahlfeld于1883年报告,但直至1954年才对本病的临床表现、生化及组织学改变有了较清楚的认识。近年来国外学者对本病的病因、发病机理、临床特征及预后的研究日益深入,并提出不少新的看法。本文就其研究进展作一扼要综述。病因病因迄今尚未明确,推测与下列因素有关。一、类固醇代谢紊乱有人认为本病与某种合成代谢的类固醇有一定关系,特别是17-α烷基被取代的类固醇,此类激素可引起类似本病的组织变化、生化改变和临床症状。Laatikainen等指出患本病的孕妇,其胎儿类固醇合成障碍,尤其是胎儿的肝脏将16-α羟基去氢表雄酮 Cholestasis of liver during pregnancy, also known as pregnancy idiopathic jaundice or pregnancy recurrent jaundice. The disease was first reported by Ahlfeld in 1883, but it was not until 1954 that the clinical manifestations, biochemical and histological changes of the disease were clearly understood. In recent years, foreign scholars on the etiology, pathogenesis, clinical features and prognosis of the increasingly in-depth, and put forward many new ideas. This article gives a brief overview of its research progress. The etiology of etiology has not yet been clear, speculated that the following factors. First, the steroid metabolic disorder Some people think that the disease and some anabolic steroids have a certain relationship, in particular 17-alpha alkyl substituted steroids, these hormones can cause similar tissue changes in this disease, biochemical changes and clinical symptoms. Laatikainen, etc. pointed out that pregnant women with this disease, its fetal steroid synthesis disorders, especially the liver of the fetus will be 16-alpha hydroxy-DHEA