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用单克隆抗体、卵白素生物素复合物法(ABC法),观察51例原发性肺癌组织中各种单核性细胞亚型的分布特点和胶原纤维反应情况。发现浸润的单核性细胞中T淋巴细胞最多,其次为单核巨噬细胞,两者除大量存在于肿瘤边缘部外,还见于肿瘤间质,乃至肿瘤实质中,与癌细胞直接接触。B淋巴细胞多集中成滤泡状,散在分布于肿瘤边缘及附近正常肺组织中。杀伤细胞/自然杀伤细胞(K/NK细胞)的数量极少。肿瘤周围胶原纤维反应程度与单核性细胞浸润程度相平行。作者认为二者都是机体肿瘤免疫的局部表现。
Using monoclonal antibodies and avidin biotin complex method (ABC method), the distribution characteristics of various mononuclear cell subtypes and collagen fibril reactions in 51 cases of primary lung cancer were observed. The infiltration of mononuclear cells was found to have the largest number of T lymphocytes, followed by mononuclear macrophages. Except for a large number of tumors located at the edge of the tumor, they were also found in the tumor stroma and even in the tumor parenchyma and were in direct contact with the cancer cells. B-lymphocytes are mostly concentrated in follicles, scattered in the edge of the tumor and near normal lung tissue. The number of killer/natural killer cells (K/NK cells) is extremely small. The extent of collagen fibrosis around the tumor was parallel to the degree of mononuclear cell infiltration. The authors believe that both are local manifestations of tumor immunity in the body.