论文部分内容阅读
乙胺碘呋酮又叫胺碘酮或安律酮,是苯呋喃类衍生物,1967年用于治疗心绞痛,1970始用于抗心律失常,我国于1978年后用于治疗各种快速心律失常收到显著疗效。胺碘酮的主要药理作用:为α和β肾上腺素能受体的非竞争性阻滞剂,可选择性扩张血管平滑肌和冠状动脉,从而降低周围血管阻力和增加冠脉流量,减低心肌耗氧量而不显著影响心排量。其电生理特性是延长心脏各部位的动作电位时间和有效不应期,特别是对窦房结与房室结的作用明显,从而有效地控制异位起搏点,并使单向阻滞变为双向阻滞,阻断了折返途径,起到控制心律失常作用。静脉给药主要作
Amiodarone, also known as amiodarone or anthrone, is a derivative of benzofuran, for the treatment of angina in 1967, 1970 for antiarrhythmic therapy and for the treatment of various tachyarrhythmia in China after 1978 Received significant effect. The main pharmacological effects of amiodarone: α and β adrenergic receptor non-competitive blockers, can selectively dilate vascular smooth muscle and coronary artery, thereby reducing peripheral vascular resistance and increase coronary flow, reduce myocardial oxygen consumption Volume without significant effect on cardiac output. Its electrophysiological properties is to extend the action potential time and effective refractory period of all parts of the heart, especially for the sinus node and atrioventricular node obvious effect, so as to effectively control ectopic pacemaker, and to unidirectional block change For two-way block, blocking the turnaround, play a role in controlling arrhythmia. Mainly for intravenous administration